文学

螺旋藻中的肽类分子或具有明显的降血压效应

螺旋藻中的肽类分子或具有明显的降血压效应

Consideredasasuperfoodofthefuture,Spirulinaplatensismatrixhasbeenextensivelyusedbeca,itsnutraceuticalproperties,bioactivecompounds,,wedemonstratethatSplatensismatrixprocessedinvitrobysimulatedgastrointestinaldigestioninducesdirectendothelialnitricoxide(NO)-,weusedacomplexmultisteppeptidomicapproachtofractionatethecrudedigest:ofthe5peptidefractionsidentified(A-E),senceof4mainpeptides(SP3-SP6[spirulinapeptides]),ofwhichonlySP6(GIVAGDVTPI)exerteddirectendothelium-dependentvasodilationofexvivovessels,aneffectoccurringviaaPI3K(phosphoinositide-3-kinase)/AKT(serine/threoninekinaseAkt),administrationofSP6evokedasignificanthemodynamiceffect,reducingbloodpressure,anactionabsentineNOS(endothelialNOsynthase)-de?,althoughlowerdosesofSP6hadnohemodynamiceffects,,inanexperimentalmodelofarterialhypertension,SP6exertedanantihypertensiveeffect,improvingen,thisnoveldecamericpeptidemayextendthepossiblefieldsofapplicationforspirulina-derivedpeptidesandcouldbedevelopedintoapromisingnonpharmacologicalapproachforthecontainmentofpathologiesassociatedwithvascularNOmisregulation.。

提供的文章均由网友转载于网络,若本站转载中的文章侵犯了您的权益,请与本站管理员联系.
Copyright © 2006-2019 文学_当代文学www.hy9996.com All Rights Reserved.